Corneal hysteresis as a risk factor for optic nerve head surface depression and retinal nerve fiber layer thinning in glaucoma patients

Abstract To evaluate the role of corneal hysteresis (CH) as a risk factor for progressive ONH surface depression and RNFL thinning measured by confocal scanning laser ophthalmoscopy (CSLO) spectral-domain optical coherence tomography (SD-OCT), respectively in glaucoma patients. Prospective study. A total 146 eyes 90 patients with were recruited consecutively. The CH measurements acquired at baseline 4-months interval using Ocular Response Analyzer (Reichert Instruments, Depew, NY). Eyes imaged CSLO (Heidelberg Retinal Tomograph [HRT]; Heidelberg Engineering, GmbH, Dossenheim, Germany) SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec AG, Dublin, CA) approximately 4-month intervals measurement topography thickness, respectively. Significant defined reference to Topographic Change Analysis (TCA) HRT Guided Progression (GPA) Cirrus HD-OCT, Multivariate cox proportional hazards models used investigate whether is progression after adjusting potential confounding factors. All followed an average 6.76 years (range, 4.56–7.61 years). Sixty-five glaucomatous (44.5%) 49 showed depression, 55 (37.7%) 43 had 20 (13.7%) 17 visual field progression. In model, diastolic IOP, CCT, age, disc area MD, was significantly associated (HR = 0.71, P 0.014 HR 0.54, 0.018, respectively), but not 1.03, 0.836). For each 1-mmHg decrease CH, increase 29%, 46%. lower increased